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http://www.iephb.nw.ru/labs/lab38/spirov/hazard/saccharin.html
HAZARD Database
Saccharin | [81-07-2] | ||||
| Synonyms: 1,1-dioxide-1,2-Benzisothiazol-3-(2H)-one; 1,2-Benzisothiazol-3(2H)-one-1,1-dioxide; 3-benzisothiazolinone 1,1-dioxide; o-benzoic sulfimide; benzoic sulfimide; benzo-2-sulfimide; benzosulfinide; o-benzoyl sulfimide; 3-hydroxybenzisothiazole-S,S-dioxide; 1,2-benzisothiazolin-3-one, 1,1-dioxide; anhydro-o-sulfaminebenzoic acid; o-benzosulfimide; natreen; sacarina; sucre edulcor; sucrette; 2-sulfobenzoicimide; syncal; zaharina; 1,2-dihydro-2-ketobenzisosulfonazole; 2,3-dihydro-3-oxobenzisosulfonazole; kandiset; garantose; glucid; gluside; hermesetas; saccharin acid; 550 saccharine; saccharin insoluble; saccharinol; saccharinose; saccharol; o-sulfobenzimide; o-sulfobenzoic acid imide; benzosulfimide; insoluble saccharin; saccharimide; 1,1-Diox-1,2-benzisothiazol-3-one | |||||
| C7H5NO3S 183.18 | |
| 228.8 | 0.828 | ||
| (subl) | -- | ||
| -- | Slightly soluble. >=10 g/100 mL at 24 C | ||
| -- | U202 | ||
| -- | DE4200000 | ||
| Artificial sweetener. White crystals | |||
More information about this substance is available from:
- Available Chemicals Exchange
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- Berkeley Carcinogenic Potency Database
- California EPA List of Lists
- Center for Food Safety & Applied Nutrition
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- Current List of Toxics Release Inventory Chemicals
- Database on Promoters of Chemical Carcinogesis
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- Environmental Science Center database of Experimental Log P coefficients, with Ozone Depletion Potentials and Atmospheric Oxidation Rates
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- EPA factsheets for regulated chemicals
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- Existing Chemicals: Literature Reviews and Evaluations
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- IARC Evaluations of Carcinogenicity to Humans
- Known Carcinogens, 8th Annual Report on Carcinogens
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- MedChem CLogP values for some drugs
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- NASA Department of Environmental Services List Of Lists of Regulated Chemicals
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- New Jersey Right to Know Hazardous Substance Fact Sheets
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- NTP Chemical Health and Safety Data
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- OSHA Chemical Sampling and Methods
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- Phys. Nutrition Encyclopedia
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- Picatinny Arsenal
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- Pollution Prevention Progress Measurement Method (3P2M) Hazard Ranking
- Preservatives
- Procedures for handling carcinogens at Rochester
- Proton NMR Spectral Molecular Formula Index
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- Title III List of Lists
- TRI Chemicals in other Federal Programs: Regulatory Matrix
- UMCP Partial list of mutagens
- UMCP Partial list of teratogens
- UMCP Select list of carcinogens
- University of California-Riverside list of compounds that must be reported
- Web Molecules (in VRML)
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Common Name: Saccharin CAS Number: 81-07-2 DOT Number: None Date: July, 1986 ----------------------------------------- HAZARD SUMMARY * Saccharin can affect you when breathed in. * Saccharin is a CARCINOGEN--HANDLE WITH EXTREME CAUTION. * Exposure to high levels can cause loss of appetite, nausea, vomiting and diarrhea. * Saccharin can cause a general allergic reaction with rash and itching. IDENTIFICATION Saccharin is a white crystalline powder or solid. It is used as a dietetic sweetener in soft drinks, juices and chewing gum. REASON FOR CITATION * Saccharin is on the Hazardous Substance List because it is cited by NTP and CAG. * This chemical is on the Special Health Hazard Substance List because it is a CANCER-CAUSING AGENT. HEALTH HAZARD INFORMATION Acute Health Effects The following acute (short-term) health effects may occur immediately or shortly after exposure to Saccharin: * Exposure to high levels can cause loss of appetite, nausea, vomiting and diarrhea. Chronic Health Effects The following chronic (long-term) health effects can occur at some time after exposure to Saccharin and can last for months or years: Cancer Hazard * Saccharin is a PROBABLE CARCINOGEN in humans. There is some evidence that it causes urinary tract cancer in humans and it has been shown to cause bladder cancer in animals. * Many scientists believe there is no safe level of exposure to a CARCINOGEN. Such substances may also have the potential for causing reproductive damage in humans. Reproductive Hazard * There is no evidence that Saccharin affects reproduction. This is based on test results presently available to the New Jersey Department of Health from published studies. Other Long-Term Effects * Exposure to Saccharin can cause a general allergic reaction with rash and itching. Common Name: Saccharin DOT Number: None DOT Emergency Guide code: CAS Number: 81-07-2 --------------------------------------- Hazard rating NJ DOH NFPA FLAMMABILITY - Not Rated REACTIVITY - Not Rated --------------------------------------- CANCER CAUSING AGENT POISONOUS GASES ARE PRODUCED IN FIRE --------------------------------------- Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe PHYSICAL DATA Water Solubility: Slightly soluble CHEMICAL NAME 1,1-Dioxide-1,2-Benzoisothiazol-3(2H)-one ------------------------------------------ Not intended to be copied and sold for commercial purposes. ------------------------------------------ NEW JERSEY DEPARTMENT OF HEALTH Right to Know Program CN 368, Trenton, NJ 08625-0368 ------------------------------------------ ------------------------------------------ ECOLOGICAL INFORMATION Saccharin is an artificial non-caloric sweetner which has been used as a substitute for sucrose. It may enter the environment from industrial discharges, municipal waste treatment plant discharges, or spills. ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS Acute toxic effects may include the death of animals, birds, or fish, and death or low growth rate in plants. Acute effects are seen two to four days after animals or plants come in contact with a toxic chemical substance. Based on tests with the sodium salt hydrate, saccharin has slight acute toxicity to aquatic life. Insufficient data are available to evaluate or predict the short-term effects of saccharin to plants, birds, or land animals. CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS Chronic toxic effects may include shortened lifespan, reproductive problems, lower fertility, and changes in appearance or behavior. Chronic effects can be seen long after first exposure(s) to a toxic chemical. Based on tests with the sodium salt hydrate, saccharin has slight chronic toxicity to aquatic life. Insufficient data are available to evaluate or predict the long-term effects of saccharin to plants, birds, or land animals. WATER SOLUBILITY Saccharin is highly acidic and highly soluble in water. Its solubility is increased in the form of either the sodium or calcium salt. Concentrations of 1,000 milligrams and more will mix with a liter of water. DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT Saccharin is moderately persistent in water, with a half-life of between 20 to 200 days. The half-life of a pollutant is the amount of time it takes for one-half of the chemical to be degraded. About 99.9% of saccharin will eventually end up in water; the rest will end up in terrestrial soils and aquatic sediments. BIOACCUMULATION IN AQUATIC ORGANISMS Some substances increase in concentration, or bioaccumulate, in living organisms as they breathe contaminated air, drink contaminated water, or eat contaminated food. These chemicals can become concentrated in the tissues and internal organs of animals and humans. The concentration of saccharin found in fish tissues is expected to be about the same as the average concentration of saccharin in the water from which the fish was taken. SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S. EPA.
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